Rev Proc 2013-13 announces a new, optional safe harbor for home office expenses.
For taxable years beginning on or after 1 Jan 2013 a taxpayer can choose to forego allocating expenses and figuring depreciation to determine the home office deduction.
Instead, they can simply calculate the square footage of the area that is a qualified business use (the usual regular and exclusive use test appears to apply) not to exceed 300 sq ft and then multiply it by an IRS-set rate (current $5/sq ft).
The election for a given year is irrevocable for that year, but you can change back and forth from year to year without the need for IRS permission. Any year you choose the safe harbor you do not take depreciation and the allowable depreciation for that portion of the home for that year is also zero.