If the test button in the RMS Peripherals screen is greyed out then that is definately related to your problem. It indicates that either RMS does not think that you have enabled the cash drawer (which your earlier poasts say you have) or that RMS was not able to Claim the cash drawer when it started up. We use Epson printers pretty much exclusively (I have a few upgrade customers that had existing Star or Ithica printers). The only time I have seen problems getting the cash drawer recognized was when there was an error condition on the printer (usually out of paper).
You may want to try adjusting the pulse voltage for the cash drawer in EpsonOPOS utility - I've had to do that on AGP drawers before - but if it opens in the OPOS Utility it should open in RMS...
Here's a wild guess - check the cashier properties and make sure the cashier isn't set up to use Drawer 2...
Maybe try setting up Cash Drawer 2 to use the same drawer and see if that one gets activated in the peripherals test screen in RMS.
Good Luck!